人类微生物群是SARS-CoV-2突变的有益储存库
Birong Cao1,2,3, Xiaoxi Wang1,2, Wanchao Yin1,2,4
1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
mBio
|March 26, 2024
概括
人类微生物组可能通过提供有益的突变来促进SARS-CoV-2的进化. 这一发现为病毒适应和流行病应对策略提供了新的见解.
科学领域:
- 微生物学 微生物学
- 病毒学 病毒学
- 遗传学 遗传学 是一个
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 突变,特别是在尖端 (S) 蛋白中,对大流行控制构成挑战.
- 有利于SARS-CoV-2突变的快速出现,增强可传播性或免疫逃脱,仍然不太了解.
研究的目的:
- 研究人类微生物组在SARS-CoV-2突变进化的潜在作用.
- 阐明推动SARS-CoV-2适应和宿主相互作用的新机制.
主要方法:
- 在国家生物技术信息中心数据库中搜索了SARS-CoV-2突变的同源片段 (HFs).
- 分析了HFs中的细菌突变,重点关注来自人类微生物群的细菌突变.
- 研究了由SARS-CoV-2RNA依赖RNA聚合酶对细菌mRNA的复制.
主要成果:
- 在61个SARS-CoV-2尖峰和外膜蛋白中发现了细菌突变,明显超过了自然变异.
- 发现大约70%的细菌突变来自人类微生物群,主要在肺和肠道.
- 证明SARS-CoV-2可以复制嵌合RNA,结合细菌突变.
结论:
- 人类微生物组充当了SARS-CoV-2可以获得的有利突变的储存库.
- 这种机制有助于病毒适应,可能影响传播能力和免疫逃避.
- 这些发现为病毒演变提供了新的视角,并对了解和管理COVID-19产生了影响.
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