在患有慢性肺病的退伍军人中,COVID-19的严重程度和死亡率
Kristina Crothers1,2, Scott V Adams1, Aaron P Turner1,3
1Veterans Affairs Puget Sound Healthcare System, Seattle, Washington; and.
患有慢性肺病 (CLD) 的退伍军人面临更高的COVID-19严重结果风险,包括住院和死亡. 异形性肺纤维化 (IPF) 和COPD显示出与COVID-19严重程度增加的最强的关联.
科学领域:
- 肺部医学 肺部医学
- 传染病流行病学 传染病流行病学
- 临床流行病学 临床流行病学
背景情况:
- 慢性肺病 (CLD) 与更糟糕的COVID-19结果有关.
- 了解与不同CLD相关的特定风险对于患者管理至关重要.
研究的目的:
- 为了评估美国退伍军人患有各种慢性肺部疾病的严重COVID-19结果的风险.
- 为了确定特定的CLD和COVID-19严重程度之间的关联.
主要方法:
- 对美国国家队列退伍军人进行SARS-CoV-2-阳性测试的分析 (2020年3月至2021年4月).
- 利用多项回归来评估门诊,住院,严重疾病或30天内死亡的风险.
- 具有和没有CLD的退伍军人之间的比较结果,包括COPD,喘,IPF,类,和其他ILDs.
主要成果:
- 与没有CLD的退伍军人相比,患有CLD的退伍军人 (队列中的17%) 的中度,关键和致命COVID-19结局率较高.
- 异形性肺纤维化 (IPF) 与死亡率的关联最强 (aRR为1.69),其次是其他ILD和COPD.
- 喘与严重的COVID-19结局相关性较小.
结论:
- 慢性肺部疾病,特别是IPF,其他ILD和COPD,增加了退伍军人的严重COVID-19结果的可能性.
- 研究结果为患有CLD和COVID-19的退伍军人提供了医疗保健利用和预后的信息.
- 结果突出了特定的CLD对COVID-19严重性的差异影响.
更多相关视频
08:27Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury
Published on: May 21, 2018
12:21A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
Published on: September 28, 2022
相关概念视频
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Chronic Obstructive Pulmonary Disease-V: Management
Smoking Cessation
Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
