跨状交流电刺激的强度和频率特异效应是由网络动态解释的
Zhihe Zhao1, Sina Shirinpour1, Harry Tran1
1Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States of America.
Journal of neural engineering
|March 26, 2024
概括
超交替电流刺激 (tACS) 的效果依赖强度和频率. 计算模型显示,tACS非线性调节神经振荡,以更高的强度和特定频率引入神经元.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 计算生物学 计算生物学
背景情况:
- 跨交替电流刺激 (tACS) 是一种非侵入性脑刺激技术.
- tACS的目的是吸引神经活动并改变神经振荡功率.
- 基于tACS效应的精确机制仍然不完全理解.
研究的目的:
- 调查tACS的基本机制.
- 探索tACS如何调节内生神经振荡.
- 了解tACS对神经网络的强度和频率依赖的影响.
主要方法:
- 开发了一个由金字塔 (PY) 和抑制性内部神经元组成的计算神经网络模型.
- 模拟tACS与人类可实现的电场强度.
- 模拟内在网络活动和测量神经卷入.
主要成果:
- tACS效应是非线性且依赖强度的.
- 较低的tACS强度 (<0.3 mV mm-1) 会使神经发射失去同步.
- 较高的tACS强度 (>0.3 mV mm−1) 将神经元引入电场.
- 训练遵循基于刺激频率的阿诺德舌头.
- 神经网络可以放大tACS诱导的卷入.
- PY神经元直接被引进并驱动抑制性神经元.
结论:
- 为tACS对神经网络的影响提供了一个机制框架.
- 强调强度和频率在tACS参数选择中的重要性.
- 在认知神经科学和临床应用中优化tACS至关重要.
相关概念视频
Electrical Synapses
Electrical synapses found in all nervous systems play important and unique roles. In these synapses, the presynaptic and postsynaptic membranes are very close together (3.5 nm) and are actually physically connected by channel proteins forming gap junctions.
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
Muscle Stimulation Frequency
The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
Electrochemical Gradient and Channel Proteins: An Overview
An electrochemical gradient is a fundamental concept in biology and chemistry. It regulates the movement of ions across cell membranes. This movement is influenced by two factors:
The electrical gradient: The electrical gradient across cell membranes refers to the difference in electric charge between the inside and outside of a cell. This difference drives the movement of ions towards or away from the cells. For instance, if the inside of the cell is more negatively charged relative to the...
The electrical gradient: The electrical gradient across cell membranes refers to the difference in electric charge between the inside and outside of a cell. This difference drives the movement of ions towards or away from the cells. For instance, if the inside of the cell is more negatively charged relative to the...
Action Potential: Phases of Stimulation
The action potential is a complex electrical event that occurs in excitable cells, such as neurons and muscle cells. It consists of several distinct phases, each with specific characteristics.
Resting Phase:
In this phase, the cell's membrane is at its resting potential, typically around -70 millivolts (mV) for neurons. Inside the cell, there is a higher concentration of potassium ions (K+) and a lower concentration of sodium ions (Na+). Voltage-gated sodium channels are closed, and...
Resting Phase:
In this phase, the cell's membrane is at its resting potential, typically around -70 millivolts (mV) for neurons. Inside the cell, there is a higher concentration of potassium ions (K+) and a lower concentration of sodium ions (Na+). Voltage-gated sodium channels are closed, and...
Network Function of a Circuit
Frequency response analysis in electrical circuits provides vital insights into a circuit's behavior as the frequency of the input signal changes. The transfer function, a mathematical tool, is instrumental in understanding this behavior. It defines the relationship between phasor output and input and comes in four types: voltage gain, current gain, transfer impedance, and transfer admittance. The critical components of the transfer function are the poles and zeros.
Neuronal Communication
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...


