情绪稳定剂在治疗患有cPTSD并发症的双相情感患者方面有多有效? 来自观察性研究的结果
Anna Maria Iazzolino1, Marta Valenza2, Martina D'Angelo1
1Psychiatry Unit, Department of Health Sciences, University of Catanzaro Magna Graecia, Catanzaro, 88100, Italy.
International journal of bipolar disorders
|March 26, 2024
概括
患有双相情绪障碍 (BD) 和复杂创伤后应激障碍 (cPTSD) 的人对情绪稳定剂治疗的反应较差. 这表明,以创伤为重点的补充疗法可能会改善这些患者的治疗结果.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 神经科学是一个神经科学.
背景情况:
- 童年创伤增加了复杂创伤后应激障碍 (cPTSD) 的风险.
- 患有双相情感障碍 (BD) 的人患有创伤经历的患病率更高.
- 对cPTSD和BD的并发症可能会使精神病理症状恶化.
研究的目的:
- 调查伴随性cPTSD对BD患者情绪稳定剂治疗反应的影响.
- 评估创伤史和双相情感障碍治疗疗效之间的关系.
主要方法:
- 一项涉及344名被诊断患有BD类型I和II的患者的横截面研究.
- 使用国际创伤问卷对cPTSD进行查.
- 通过阿尔达尺度来评估治疗反应.
主要成果:
- 与没有cPTSD的患者相比,患有并发性cPTSD的BD患者对情绪稳定剂的反应明显较差.
- 阿尔达尺度表明在存在cPTSD时,治疗效率较低.
结论:
- 并发性cPTSD会对双相情绪障碍患者的治疗反应产生负面影响.
- 对于患有cPTSD的BD患者,需要创伤信息的附加疗法.
- 未来的研究应该专注于为这种共同疾病群体量身定制的治疗方法.
相关概念视频
Mania and Antimanic Drugs: Overview
176
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
176
Bipolar Disorder
67
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
67
Antidepressant Drugs: MAOIs and Other Agents
228
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
228
Electroconvulsive Therapy
39
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
39
Post-traumatic Stress Disorder
33
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
33
Cognitive Therapy
152
Cognitive therapy, pioneered by Aaron T. Beck in the 1960s, is a structured approach to addressing psychological distress by focusing on the influence of thoughts on emotions and behaviors. All cognitive therapies involve the basic assumption that human beings have control over their feelings, and that how individuals feel about something depends on how they think about it. Unlike psychoanalytic methods that delve into unconscious processes or humanistic approaches emphasizing...
152


