结肠直肠癌中的PD-L1表达与免疫微环境相关
Mohammed Shahin1, Susama Patra2, Suvendu Purkait1
1Department of Pathology and Lab Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Journal of gastrointestinal cancer
|March 26, 2024
概括
在结直肠癌 (CRC) 中,编程细胞死亡联体-1 (PD-L1) 表达与瘤微环境 (TIME) 中免疫细胞增加相关. 这一发现表明PD-L1可能是CRC病例的一个子集的治疗目标.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 大肠直肠癌 (CRC) 呈现出各种特征,瘤免疫微环境 (TIME) 显著影响预后.
- 编程细胞死亡连接体-1 (PD-L1) 在调节时间方面发挥作用,但其与CRC中免疫细胞概况的相关性,特别是在印度,还未得到充分研究.
研究的目的:
- 评估CRC瘤细胞中的PD-L1表达.
- 调查PD-L1与TIME的关联,不匹配修复 (MMR) 状态和印度队列中的临床病理参数.
主要方法:
- 一项涉及104个CRC病例的横截面观察研究.
- 通过免疫组织化学 (蛋白质) 和qRT-PCR (mRNA) 评估PD-L1表达.
- 免疫细胞标记物 (CD4,CD8,FOXP3,CD20,CD163) 使用ImageJ斐济平台进行量化.
主要成果:
- 21%的CRC是PD-L1阳性,在右侧瘤中更频繁.
- PD-L1阳性与显著更高的CD4+,CD8+,FOXP3+T细胞,CD20+B细胞和CD163+巨细胞度相关.
- 没有发现PD-L1表达与临床形状,等级,阶段,MMR状态或存活率之间的显著关联.
结论:
- 在这个东印度CRC队列中观察到PD-L1的频率较低.
- 瘤细胞中的PD-L1表达与瘤透免疫细胞显著相关,突出其在CRC病理生物学和TIME调节中的作用.
- 由于其在恶性瘤治疗中的影响,PD-L1在一定比例的CRC病例中代表着潜在的治疗标.
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