在急性缺血性中风中与自相关的5:与神经功能的变化和联系,以及生存率
Fan Chen1, Linxia Wu1, Meng Zhang1
1Department II of Emergency, Handan Central Hospital, Handan, 056008, China.
Annals of clinical and translational neurology
|March 26, 2024
概括
与血清自相关的5 (ATG5) 水平最初在急性缺血性中风 (AIS) 患者中上升,然后下降. 升高的ATG5与更糟糕的结果有关,包括神经功能障碍,复发和死亡率.
科学领域:
- 生物医学科学 生物医学科学
- 神经学 神经学
- 分子生物学分子生物学
背景情况:
- 与自相关的5 (ATG5) 在急性缺血性中风 (AIS) 发病过程中起作用.
- 了解AIS预后的生物标志物至关重要.
研究的目的:
- 研究AIS患者血清ATG5水平与临床结果之间的关联.
- 评估ATG5作为AIS的潜在预后标志物.
主要方法:
- 使用ELISA测量了280名AIS患者的血清ATG5水平,在多个时间点 (入院,D1,D3,D7,D30,D90) 测量.
- 为了进行比较,包括了50个健康对照.
- 临床结局包括修改的兰金尺度 (mRS) 评分,复发和存活率,均在21.1个月的中位随访期内进行评估.
主要成果:
- 与健康对照组相比,AIS患者的血清ATG5显著升高,与高脂血症和NIH中风量表得分相关.
- ATG5水平在D1达到峰值,并在D90.0逐渐下降.
- 在不同的时间点,较高的ATG5水平与功能性结果较差 (mRS>2),复发率增加和死亡率更高有关.
- 升高的ATG5预测了更短的无复发和整体存活时间.
结论:
- 血清ATG5在AIS之后表现出动态变化,最初增加,然后下降.
- 血清ATG5升高是AIS患者神经功能障碍,复发风险和死亡率的重要指标.
- 在急性缺血性中风管理中,ATG5可以作为一个有价值的预后生物标志物.
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