在胰腺癌瘤患者中预测长期疾病特异性存活的流行病学和预后诺莫格拉姆:基于SEER的研究
Hai Lin1, Yufang Li, Yutong Chen
1From the Department of Cancer Center, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai City, Guangdong Province, China.
Pancreas
|March 26, 2024
概括
自2000年以来,胰腺癌类瘤 (PCT) 的发生率显著增加. 研究人员使用预后因素开发了一个名录,以准确预测PCT患者的长期疾病特异性生存率 (DSS).
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 医学统计 医学统计
背景情况:
- 胰腺癌类瘤 (PCT) 是一种罕见的恶性瘤,流行病学趋势和预后因素不明.
- 准确预测长期结果对于有效的患者管理至关重要.
研究的目的:
- 调查胰腺癌瘤 (PCT) 的流行病学特征.
- 在PCT患者中确定疾病特异性生存 (DSS) 的独立预后因素.
- 开发和验证用于预测PCT患者长期DSS的预后性名录.
主要方法:
- 利用来自监测,流行病学和最终结果 (SEER) 数据库的2447名PCT患者的数据.
- 将数据分为培训 (1959名患者) 和验证 (488名患者) 队列.
- 计算了流行病学趋势和确定了预后因素,以构建一个名谱,使用C指数和校准图表评估其准确性.
主要成果:
- 在2000年至2018年期间,PCT的发病率显著增加.
- 一年,5年和10年的疾病特异性生存率分别为96.4%,90.3%和86.5%.
- 年龄,阶段,手术,放射治疗和化疗被确定为独立的预后因素. 在两个队伍中,名图表表现出高的分辨准确性和预测能力.
结论:
- 胰腺癌瘤 (PCT) 发病率自2000年以来迅速增加.
- 为预测PCT患者的长期疾病特异性存活率 (DSS),开发了一种实用,有效和准确的预后名录.
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