HyperTMO:基于超图形卷积网络的可信的多omics集成框架,用于患者分类
Haohua Wang1, Kai Lin1, Qiang Zhang1
1School of Computer Science and Technology, Dalian University of Technology, Dalian, Liaoning 116024, China.
Bioinformatics (Oxford, England)
|March 26, 2024
概括
一个新的框架HyperTMO增强了多omics数据集成,用于使用超图卷积网络进行患者分类. 这种方法可以提高对乳腺癌和阿尔茨海默氏症等疾病的分类准确度.
科学领域:
- 生物医学信息学是生物医学信息学.
- 计算生物学是一种计算生物学.
- 机器学习 机器学习
背景情况:
- 高通量技术为人类疾病研究生成详细的多学科数据.
- 基于机器学习的多omics集成提供了全面的见解,但在数据表示和集成方面面临挑战.
研究的目的:
- 介绍HyperTMO,一种用于使用超图形卷积网络进行患者分类的可信多态集成的新框架.
- 应对单个学科数据表示和整合多学科信息的挑战.
主要方法:
- HyperTMO构建了超图结构,以表示单个omics数据中的关联.
- 证据提取是使用超图卷积网络进行的.
- 多主题信息在证据层面上被整合在一起.
主要成果:
- 在乳腺癌亚型和阿尔茨海默病分类方面,HyperTMO的性能优于最先进的方法.
- 实验使用来自TCGA (BRCA) 和ROSMAP数据集的多omics数据.
- 该框架展示了准确和稳定的性能.
结论:
- HyperTMO是第一个整合超图结构,证据理论和多omics整合用于患者分类的框架.
- 该方法显示了临床诊断应用的巨大潜力.
- 该框架和数据集公开可供进一步研究使用.
相关概念视频
Integrated Healthcare System
1.6K
An integrated healthcare system (IHS) is a set of organizations that provides for or arranges to provide coordinated and continuous service to a defined population. The IHS takes responsibility for that particular population's health status and outcome, both clinically and fiscally. An integrated healthcare system is a well-organized, well-coordinated, and collaborative network. The integrated delivery system is a network that connects different healthcare providers to deliver organized,...
1.6K
Classification of Illness
7.5K
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
7.5K
Nursing Clinical Information System
773
Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
773
Issues And Trends In Healthcare Delivery System
5.6K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
5.6K
Classification of Connective Tissues
10.6K
The connective tissues have different properties and functions in the human body. They are broadly categorized into proper, supporting, or fluid connective tissues.
Connective Tissue Proper
Connective tissue proper is the most abundant class of connective tissues. As its name implies, it predominantly connects different tissues in the body. Depending on the cell types, ground substance, viscosity, and fiber types in the ECM, connective tissue proper is further categorized into loose and dense....
Connective Tissue Proper
Connective tissue proper is the most abundant class of connective tissues. As its name implies, it predominantly connects different tissues in the body. Depending on the cell types, ground substance, viscosity, and fiber types in the ECM, connective tissue proper is further categorized into loose and dense....
10.6K
Methods of Documentation VI: Case Management Model
571
The case management model is a multidisciplinary approach that involves healthcare professionals from diverse disciplines, such as physicians, nurses, therapists, social workers, and pharmacists, working collaboratively to address the various needs of patients. Each healthcare professional brings unique expertise and perspectives, contributing to a more comprehensive understanding of the patient's condition and tailoring treatment plans accordingly.
For example, a patient with a chronic...
For example, a patient with a chronic...
571


