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Updated: Jun 29, 2025

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
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Published on: January 7, 2019

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由CSF3R突变体诱导的增强MAPK信号传递赋予了对DUSP1的依赖性,用于白血病转化

Meenu Kesarwani1, Zachary Kincaid1, Mohammad Azhar1

  • 1Division of Pathology, Cincinnati Children's Hospital, Cincinnati, OH.

Blood advances
|March 26, 2024
PubMed
概括

在CSF3R驱动的白血病中准双特异性酸酶1 (DUSP1) 提供了一个新的治疗策略. 抑制DUSP1,以及MEK,通过触发亡,在小鼠中根除了白血病.

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