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相关概念视频

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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相关实验视频

Updated: Jul 2, 2026

Mouse Genome Engineering Using Designer Nucleases
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鼠标基因组信息学:用于实验室老鼠的综合知识库系统.

Richard M Baldarelli1, Cynthia L Smith1, Martin Ringwald1

  • 1The Jackson Laboratory, Bar Harbor, ME 04609, USA.

Genetics
|March 26, 2024
PubMed
概括
此摘要是机器生成的。

鼠标基因组信息学 (MGI) 为人类疾病研究提供了关于鼠标遗传学和基因组学的精选数据. 最近的更新增强了鼠标基因组数据库 (MGD) 和基因表达数据库 (GXD) 以更好地整合和访问数据.

关键词:
基因表达的基因表达方式遗传学 遗传学 遗传学 是一个基因组信息学 基因组信息学模型生物模型生物.鼠标模型 鼠标模型现象类型 现象类型

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相关实验视频

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科学领域:

  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.
  • 鼠标模型 鼠标模型

背景情况:

  • 小鼠基因组信息学 (MGI) 是小鼠遗传学和基因组学研究的关键资源.
  • 它整合了关于小鼠基因组特征,变异,表达和表型的数据.
  • MGI支持使用小鼠模型对人类生物学和疾病的研究.

研究的目的:

  • 提供MGI核心数据类型的概述.
  • 突出MGI最近的改进,重点关注MGD和GXD.
  • 为研究人员展示新的数据和功能.

主要方法:

  • 使用专业策划的信息资源.
  • 采用受控的词汇和生物本体学来进行数据注释.
  • 遵守国际社区对命名和数据集成的标准.

主要成果:

  • MGI提供了关于小鼠基因组特征,变异,表达,基因功能和表型的综合数据.
  • 该资源提供了以人类可读和计算准备的格式访问符合FAIR的数据.
  • 最近的改进侧重于MGD和GXD中的新数据和功能.

结论:

  • MGI是小鼠基因组学和疾病建模的核心社区资源.
  • 持续发展的MGI,特别是MGD和GXD,增强了它对各种研究人员的实用性.
  • MGI促进数据标准化和可访问性,以促进生物研究的发展.