具有免疫能力的孤立大脑粘膜瘤与阻塞性水脑一起呈现:说明案例
Khoa N Nguyen1, Lindsey M Freeman1, Timothy H Ung1
11Department of Neurosurgery, University of Colorado Anschutz Medical Center, Aurora, Colorado; and.
Journal of neurosurgery. Case lessons
|March 26, 2024
概括
孤立的脑粘膜,一种罕见的真菌感染,可以导致免疫能力强的成年人阻塞性水脑. 这一案例突出显示了Rhizopus真菌腹腔炎作为潜在的原因,即使没有典型的神经成像迹象.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 菌类学 菌类学是指菌类学.
背景情况:
- 隔离性脑粘膜菌是一种不常见的疾病,免疫能力强的成年人.
- 很少报告与阻塞性水脑有关.
- 中枢神经系统 (中枢神经系统) 粘膜菌通常涉及犀牛轨道或其他系统性部位.
研究的目的:
- 报告一个单一的中枢神经系统粘膜的次要阻塞性水脑病例.
- 描述单独的脑粘膜瘤瘤的手术治疗,呈现为腹腔炎.
- 审查关于中枢神经系统粘性菌和中枢神经系统在免疫能力强的患者中的文献.
主要方法:
- 一个23岁的免疫能力强的患者的病例报告.
- 在第三心室内阻塞性质量损伤的内镜鉴定.
- 微生物学证实了Rhizopus真菌腹腔炎的发生.
- 手术治疗包括脑脊髓液转移和内镜第三心室静脉切除术.
- 用内/输液安波特里辛B和口服抗真菌药物进行治疗.
主要成果:
- 诊断孤立的大脑粘膜 (Rhizopus) 导致腹腔炎和阻塞性水脑炎.
- 成功的手术和医疗管理导致患者的缓解.
- 在初始神经成像中没有典型的传染病后续.
结论:
- 在免疫能力强的成年人中,孤立的脑粘膜瘤可以呈现为腹腔炎和阻塞性水脑炎.
- 这一案例凸显了在无法解释的神经病态表现时考虑真菌感染的重要性.
- 内镜技术对于诊断和管理深层中枢神经系统的真菌病变是有价值的.
相关概念视频
Bacterial Meningitis I: Introduction
31
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
31
Bacterial Meningitis II: Pathophysiology
45
Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
45
Brain Abscess l: Introduction
47
A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial...
47
Increased Intracranial Pressure l: Introduction
30
Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component...
30
Increased Intracranial Pressure ll: Pathophysiology
39
Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins...
39
Cerebral Edema ll: Pathophysiology
31
Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this...
31


