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评估在Xenopus laevis胚胎和幼虫中 perfluoroalkyl和polyfluoroalkyl物质的潜在发育毒性

Sigmund J Degitz¹, Philip P Degoey¹, Jonathan T Haselman¹

¹US Environmental Protection Agency, Office of Research and Development, Center for Computational Toxicology and Exposure (CCTE), Great Lakes Toxicology and Ecology Division (GLTED), Duluth, Minnesota, USA.

Journal of applied toxicology : JAT

|March 26, 2024

概括

两种特定的per-和多醇基物质 (PFAS),FC10-diol和FHxSA,在Xenopus laevis胚胎中引起了显著的发育毒性和形. 幼虫暴露于PFHxS和PFOS影响了生长,但甲状腺功能没有受到影响.

科学领域:

环境毒理学环境毒理学
发展生物学发展生物学
生态毒理学生态毒理学

背景情况:

和多基基物质 (PFAS) 是令人担忧的环境污染物.
美国环保署正在调查PFAS的生态影响.
像Xenopus laevis这样的两动物是发育毒性研究的敏感模型.

研究的目的:

在Xenopus laevis胚胎中评估各种PFAS化合物的发育毒性.
研究特定的PFAS (PFOS,PFHxS,PFOA,HFPO-DA) 对幼虫生长和变形的影响.

主要方法:

胚胎暴露在17种不同的PFAS中,从中芽细胞阶段到器官生成.
幼虫暴露在PFOS,PFHxS,PFOA和HFPO-DA中,从前变形到前变形.
使用了静态更新和流通式曝光设计.

主要成果:

在测试度下,FC10-diol和FHxSA导致显著的胚胎死亡率,发育不良和发育延迟.
PFHxS和PFOS暴露影响了幼虫的生长,但PFOA和HFPO-DA没有.
在幼虫中没有观察到对甲状腺激素控制的终点有重大影响.

结论:

在不同的PFAS结构中,对发育的毒性有很大差异.
FC10-diol和FHxSA对两动物的发展构成风险.
PFAS可能会影响两动物的生长,强调需要进一步评估生态风险.

关键词:

在PFAS中,有很多方法.两动物两动物发展性毒性发展性毒性内分泌系统内分泌系统内分泌幼的子 (Tadpoles) 是一个小子.

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