增加认知活动参与对主观认知衰退的老年人默认模式网络的影响:一项随机对照试验
Allen Ting Chun Lee1, Yishan Luo2, Zhaohua Huo1
1Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
EBioMedicine
|March 26, 2024
概括
增加像书法这样的认知活动可能会增强老年人的大脑连接. 这项研究发现,加倍的练习时间积极调节了默认模式网络,这表明对晚年大脑健康有好处.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 老年学是一门学科.
背景情况:
- 认知活动可以预防痴呆症,但它们对功能性大脑网络的影响尚未得到充分证实.
- 研究了具有主观认知衰退 (SCD) 和定期认知活动参与的老年人.
- 默认模式网络 (DMN) 对认知功能至关重要,并且在衰老中经常受到影响.
研究的目的:
- 为了研究增加认知活动 (书法实践) 对SCD的老年人DMN的影响.
- 为了确定增强的认知参与是否调节功能性大脑网络连接.
- 为认知活动在维持晚年大脑健康方面的作用提供证据.
主要方法:
- 一个随机对照试验 (RCT) 涉及社区生活的55-75岁的中国成年人患有SCD.
- 参与者被随机分配到一个干预组 (双重书法实践) 或一个控制组 (常规实践) 六个月.
- 使用fMRI评估了DMN的功能连接 (FC),包括mPFC,IPL,HF,PCC和LTC等关键区域,并将其与各组进行了比较.
主要成果:
- 观察到DMN功能连接的群体间显著差异.
- 具体而言,增加书法实践导致中部前额叶皮层 (mPFC) 与右侧皮层 (LTC) 之间的FC增强.
- 另外,在mPFC和右下壁叶 (IPL) 之间,以及在左海马形成 (HF) 和右LTC/IPL之间发现了其他显著的调制.
结论:
- 增加的书法实践表明了对默认模式网络的积极神经调节效应.
- 在晚年参与更多的认知活动对于促进更好的大脑健康至关重要.
- 这些发现支持使用认知参与作为一种策略,以保持老年人的神经完整性.
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