身体活动可以缓解心血管疾病风险负担与老年人认知能力之间的关系
Sandra T Nguyen1, Jing Guo2, Suhang Song2,3
1Department of Neurology, Columbia University, New York, New York, USA, stn061@ucsd.edu.
身体活动 (PA) 可以帮助老年人通过减轻心血管疾病 (CVD) 的负面影响来维持认知功能. 这种益处在携带APOE-ɛ4基因变异的个体中尤为明显.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 的负担增加了老年人痴呆症的风险.
- 身体活动 (PA) 是心血管疾病,认知衰退和痴呆症的关键预防策略.
研究的目的:
- 调查PA是否能缓和心血管疾病负担与认知功能之间的关联.
- 为了确定PA的缓解效果是否因种族/种族或APOE-ɛ4状态而有所不同.
主要方法:
- 从华盛顿海茨-因伍德哥伦比亚老龄化项目 (WHICAP) 的2,122名非痴呆老年人 (≥65岁) 的横截面研究.
- 参与者接受了面试和神经心理评估,以了解全球认知,记忆,语言,视觉空间和速度功能.
主要成果:
- 较高的心血管疾病负担与较差的全球,语言,速度和视觉空间认知功能相关.
- 可以减轻心血管疾病对视觉空间功能的负面影响.
- 在APOE-ɛ4载体中,PA对全球认知,语言和视觉空间功能的缓解作用是显著的,但在非载体中并非如此.
结论:
- 它可以保护认知功能免受心血管疾病相关的衰退,特别是在APOE-ɛ4载体中.
- 对心血管疾病认知关系的PA缓解效应在种族/种族群体中是一致的.
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