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Updated: Jun 29, 2025

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
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在怀孕前,怀孕期间和怀孕后,佩拉曼奈尔的药理动力学和细胞染色体P450 3A4活性发生变化

Yoshiaki Yamamoto1,2, Naoto Akita1, Hiroki Nogimoto1

  • 1Department of Clinical Pharmaceutics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.

Therapeutic drug monitoring
|March 27, 2024
PubMed
概括

在患有的妇女怀孕期间,佩拉曼奈尔的药理动力学和细胞染色体P450 3A4 (CYP3A4) 活性保持稳定. 这表明,根据4β-基胆固醇 (4β-OHC) 生物标志物数据,孕期不会显著影响帕拉曼奈尔水平.

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