使用兄弟姐妹数据对回顾性出生地点回忆的准确性进行分析
Stephanie von Hinke1,2,3, Nicolai Vitt4
1School of Economics, University of Bristol, Bristol, United Kingdom. s.vonhinke@bristol.ac.uk.
Nature communications
|March 27, 2024
概括
调查中的回顾性出生地点数据通常是不准确的,报告错误率很高. 这种报告错误可能会导致基于位置的暴露研究中的偏差,特别是在兄弟固定效应模型中.
科学领域:
- 流行病学 流行病学
- 生物统计学 生物统计学
- 地理空间分析是什么
背景情况:
- 许多大规模调查依赖于参与者自我报告的出生地点.
- 准确的位置数据对于调查环境或地理暴露的流行病学研究至关重要.
- 之前的研究还没有完全量化了回顾性出生地点数据中错误报告的程度.
研究的目的:
- 评估英国生物银行的回顾性出生地点数据的准确性.
- 量化错误报告出生坐标,当地地区和县的概率.
- 评估报告错误对基于位置的暴露分析偏差的影响.
主要方法:
- 利用了来自英国生物库的完全兄弟姐妹的样本.
- 与不同年龄差异的兄弟姐妹之间比较报告的出生地点.
- 家庭迁移和出生地点错误报告的估计概率.
- 分析了报告错误对暴露结果关联中减弱偏差的影响.
主要成果:
- 在回顾性出生地点数据中发现了显著的不准确性:28%的出生坐标,16%的当地地区和6%的县被错误报道.
- 证明这种错误会导致基于位置的暴露研究中的显著减弱偏差.
- 确定兄弟固定效应模型特别容易受到这种偏差的影响,特别是具有较低的空间相关性和暴露的时间变化.
结论:
- 追溯的出生地点数据容易出现相当大的报告错误.
- 这些不准确性可能会显著影响流行病学研究的结果,特别是在使用兄弟固定效应模型时.
- 强调需要进行敏感性分析和潜在解决方案,以减轻健康研究中报告错误的偏见.
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