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Updated: Jun 29, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

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(‒) - - 化的选择性总合成是通过tandem prins循环化/循环乙化序列实现的

Xian-Zhang Liao1,2, Ran Wang1,2, Xin Wang1,2

  • 1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 100050, Beijing, P. R. China.

Nature communications
|March 27, 2024
PubMed
概括

研究人员首次实现了复杂的Ganoderma meroterpenoid () -lucidumone.lucidumone复合物的全合成. 这种合成利用了新的循环添加和氧化策略来构建其复杂的分子架构.

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