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Updated: Jun 29, 2025

An Optical Assay for Synaptic Vesicle Recycling in Cultured Neurons Overexpressing Presynaptic Proteins
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托莫辛斯通过与含有VAMP2的模板复合体结合来减弱SNARE组合和突触抑制

Marieke Meijer1, Miriam Öttl2, Jie Yang3

  • 1Department of Human Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam University Medical Center, 1081HV, Amsterdam, The Netherlands. m.meijer@vu.nl.

Nature communications
|March 27, 2024
PubMed
概括

在SNARE复杂组装方面,Tomosyns与synaptobrevin-2/VAMP2没有竞争. 相反,tomosyns与synaptobrevin-2/VAMP2合作,通过防止SNAP-25结合来限制突触强度.

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