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相关概念视频

Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

1.3K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.3K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

469
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
469
Amnesia01:13

Amnesia

123
Amnesia is a condition marked by long-term memory loss, which impairs the ability to recall past events or create new memories.
The severity and duration of memory loss vary depending on the type and underlying cause. Amnesia is classified into two main types: retrograde and anterograde.
Retrograde amnesia is marked by the loss of memories formed before the onset of the condition. Patients may recall distant past events but often forget those occurring shortly before the incident.
Anterograde...
123
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

758
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
758
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

541
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
541
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

427
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
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相关实验视频

Updated: Jun 29, 2025

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents
08:38

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Published on: September 1, 2011

73.6K

积极的遗忘和神经精神疾病.

Jacob A Berry1, Dana C Guhle2, Ronald L Davis3

  • 1Department of Biological Sciences, University of Alberta, Edmonton, AL, T6G 2E9, Canada. jaberry@ualberta.ca.

Molecular psychiatry
|March 27, 2024
PubMed
概括

主动遗忘,一个大脑过程,删除不相关的记忆,以提高灵活性. 活动性遗忘障碍与神经精神疾病有关,这凸显了它在心理健康中的关键作用.

科学领域:

  • 神经科学是一个神经科学.
  • 分子生物学分子生物学
  • 细胞生物学 细胞生物学

背景情况:

  • 大脑在分子,细胞和网络层面使用活跃的遗忘机制.
  • 积极忘记对于行为灵活性和删除无关信息至关重要.
  • 活动性遗忘障碍与神经精神疾病有关.

研究的目的:

  • 在动物模型中阐明活跃遗忘的分子和细胞机制.
  • 探索多巴胺神经元的作用,内分泌网膜Ca2+信号传递,以及细胞骨重塑在记忆遗忘中的作用.
  • 调查网络层面的机制和与活跃遗忘中的细胞过程的潜在协调.

主要方法:

  • 在Drosophila.分子遗传和行为研究.
  • 对多巴胺-氧化联合传播和接收的研究.
  • 对内等质网膜Ca2+信号和小GTPase调节的细胞骨重塑的分析.

主要成果:

  • 在Drosophila中发现了一个复杂的活跃忘记通路系统,涉及多巴胺信号和细胞机械.
  • 这些机制,包括哺乳动物中的AMPA受体贩运调节,在物种之间得到保护.
  • 涉及非恩格拉姆神经元,神经发生和质细胞的网络层次机制也会导致主动遗忘.

更多相关视频

A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions
10:38

A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions

Published on: July 16, 2015

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Author Spotlight: Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning
14:47

Author Spotlight: Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning

Published on: April 21, 2023

2.7K

相关实验视频

Last Updated: Jun 29, 2025

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents
08:38

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Published on: September 1, 2011

73.6K
A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions
10:38

A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions

Published on: July 16, 2015

13.6K
Author Spotlight: Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning
14:47

Author Spotlight: Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning

Published on: April 21, 2023

2.7K

结论:

  • 主动遗忘是一个多层次的过程,涉及协调的细胞和网络机制.
  • 在动物模型中了解这些机制,可以了解神经精神疾病的洞察力,这些疾病的特征是记忆障碍.
  • 对主动遗忘的进一步研究可以促进我们对记忆调节及其功能障碍的理解.