符合ECMO支持的COVID-19相关ARDS患者的右心室损伤:一个多中心的回顾性研究
Matthieu Petit1,2, Misylias Bouaoud3, Edouard Jullien1
1Medical Intensive Care Unit, Ambroise Paré Hospital, APHP, 9 Avenue Charles de Gaulles, Boulogne-Billancourt, France.
Annals of intensive care
|March 27, 2024
概括
在符合ECMO条件的COVID-19急性呼吸窘迫综合征 (ARDS) 患者中,右心室损伤表明死亡风险更高. 识别这个子组可以完善ECMO选择,以获得ARDS患者更好的结果.
科学领域:
- 关键护理医学 关键护理医学
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
背景情况:
- 与COVID-19相关的ARDS具有很高的死亡率.
- 在COVID-19 ARDS中ECMO的最佳患者选择标准尚不清楚.
- 右心室 (RV) 功能评估可能有助于ECMO候选人选择.
研究的目的:
- 根据EOLIA标准确定符合ECMO条件的COVID-19ARDS患者的发病率和结果.
- 确定RV损伤 (RVI) 的患者的一个子组作为ECMO的潜在目标.
- 评估RVI与COVID-19的90天死亡率之间的关联.
主要方法:
- 在法国3个ICU进行了回顾性观察研究 (2020年3月至2021年3月).
- 包括确诊SARS-CoV-2,ARDS和可用心声图的患者.
- 将患者分为EOLIA- (没有ECMO标准),EOLIA+RVI- (ECMO标准,没有RV损伤) 和EOLIA+RVI+ (ECMO标准有RV损伤) 组.
- RVI定义为RV/LV终端-透气面积比>0.8和悖论性隔膜运动.
- 使用卡普兰-梅尔曲线和考克斯回归分析了90天死亡率.
主要成果:
- 包括283名患者;其中18名 (6.3%) 接受了ECMO.
- 在EOLIA-组: 107名患者 (40.5%);在EOLIA+RVI-组: 126名患者 (47.5%);在EOLIA+RVI+组: 32名患者 (12%).
- 90天死亡率:21% (EOLIA-),44% (EOLIA+RVI-),66% (EOLIA+RVI+) (p < 0.001) 在90天死亡率中.
- RVI与90天死亡率的增加独立相关 (HR = 1.92;95% CI [1.10-3.37]).
结论:
- 满足EOLIA标准的COVID-19 ARDS患者与RV压力过载 (RVI) 显示出特别糟糕的结果.
- 这一RVI小组 (12%的队列) 代表了ECMO考虑的更具体的目标人群.
- 需要进一步评估,以确定确定这种高风险子集如何影响以患者为中心的结果.
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