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"bIUreactor":一个开源的3D组织研究平台
Elizabeth Butch1, Matthew Prideaux2, Mark Holland1
1Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Annals of biomedical engineering
|March 27, 2024
概括
研究人员现在可以通过开源的BIUreactor平台以负担得起的方式研究3D结构组织. 这种多功能系统可以在任何实验室内以不到8,000美元的价格实现3D组织生成, perfusion 和机械加载.
科学领域:
- 生物医学工程 生物医学工程
- 组织工程是组织工程.
- 开源技术是开源技术.
背景情况:
- 研究3D结构组织对于推动生物医学研究至关重要.
- 现有的生物反应器系统可能很昂贵,许多实验室无法使用.
研究的目的:
- 开发一个负担得起的,开源的研究平台,用于研究3D结构组织.
- 为了使研究人员能够在自己的实验室中对3D组织产生,培养和应用机械刺激.
主要方法:
- 利用3D打印,开源软件和硬件创建一个模块化生物反应器系统.
- 集成用于 perfusible 3D 组织生成,氧化 perfusion 和循环压缩的组件.
- 开发开源代码来控制生物反应器系统.
主要成果:
- 宝反应器平台成功地实现了可透气3D组织的生成和培养.
- 该系统包括一个生物反应器室,循环压缩模块,以及用于含氧 perfusion 的环静电.
- 整个系统,包括3D打印机和电子设备,成本约为8,000美元.
结论:
- 开源的bIUreactor通过提供一个可访问和多功能平台,使3D组织研究民主化.
- 该倡议旨在加快利用3D组织模型进行生物医学发现的速度和规模.
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