肺纤维负担和船厂工人的恶性间皮瘤风险:基于尸体解剖的病例控制研究
Dario Mirabelli1, Anna Benedetta Somigliana2, Danila Azzolina3
1Unit of Cancer Epidemiology, Department of Medical Sciences, CPO Piemonte and University of Turin, via Santena 7, 10126 Turin, Italy (retired).
Annals of work exposures and health
|March 27, 2024
概括
造船厂工人中半质瘤的风险与接触石棉直接相关. 较高的肺石棉纤维负担,特别是两类和红类,显著增加患这种癌症的风险.
科学领域:
- 职业健康 职业健康 职业健康
- 环境流行病学环境流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 胸腔癌的发病率在意大利拥有大型造船厂的地区最高.
- 造船厂工人因历史上使用石棉而面临重大职业健康风险.
研究的目的:
- 调查石棉暴露与造船厂工人中美索瘤风险之间的暴露与反应关系.
- 量化肺部石棉纤维负担与间皮瘤发病率之间的关联.
主要方法:
- 一项基于尸体解剖的病例对照研究,涉及102名间皮瘤死者和84名肺癌对照.
- 使用扫描电子显微镜和X射线光仪测量肺部石棉纤维含量.
- 后勤回归分析以评估基于纤维类型和负担的间皮瘤的几率比率,以混因子进行调整.
主要成果:
- 较高的肺石棉纤维负担与中皮瘤的几率比率显著增加有关 (OR=22.0为最高类别).
- 间皮瘤的风险与肺部的总体,两体和状石棉纤维负担成比例增加.
- 肺部石棉负担增加10倍与中瘤风险增加3.71倍相关.
结论:
- 在造船厂工人中,间皮瘤的风险明显与累积的石棉暴露成正比.
- 两种类型的石棉纤维和石棉纤维都会导致间皮瘤的发展.
- 肺纤维负担作为一个可量化的生物标志物用于石棉相关的癌症风险.
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