肺部在COVID-19后对一氧化碳和氧化的扩散能力:一项前性队列研究 (SECURe研究)
Anna Agnes Lytzen1, Thora Wesenberg Helt2, Jan Christensen3
1Centre for Physical Activity Research, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Experimental physiology
|March 27, 2024
概括
在COVID-19后持续的肺功能下降被使用双气体测试来研究. 虽然肺容量有所改善,但一年后大多数患者的肺容量仍然异常,与身体表现的提高没有明确的联系.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 心血管呼吸系统生理学
背景情况:
- 持续的肺扩散能力异常在COVID-19后很常见.
- 双测试气体方法 (DL,CO,NO) 综合评估肺功能.
- 了解长期的COVID-19呼吸系统后果至关重要.
研究的目的:
- 在COVID-19后的患者中,评估一氧化碳和氧化 (DL,CO,NO) 度量表的双重测试气体扩散能力.
- 检查DL,CO,NO指标,COVID-19严重程度和身体表现之间的关系.
- 随着时间的推移,跟踪肺功能和身体表现的变化.
主要方法:
- 一组148名COVID-19患者在5.7个月的随访期间进行了DL,CO,NO测量.
- 异常的DL,CO,NO指标包括氧化 (DL,NO) 和一氧化碳 (DL,CO,5s) 的肺扩散能力.
- 在5.7个月和12.5个月使用30秒的坐立和6分钟的步行测试来评估身体表现.
主要成果:
- ~60%的患者在5.7个月后显示了DL,CO,NO指标的严重程度下降.
- 在12.5个月后,DL,NO和DL,CO,5s有所改善,但在三分之二的患者中仍然异常.
- 身体表现有所改善,但与DL,CO,NO指标没有相关性.
结论:
- 根据COVID-19的严重程度,DL,NO和DL,CO的下降在5.7个月后显而易见.
- 大多数患者在COVID-19后12.5个月内仍然存在肺功能异常.
- 身体表现的改善与肺扩散能力的恢复没有直接关联.
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