在患有局部晚期 (IIA-IVA) 下食道癌患者的手术坚持和生存结果:基于SEER数据库的研究
Jingsong Liu1, Hu Chen2, Chuannan Wu3,4
1Department of Thoracic Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
The American surgeon
|March 27, 2024
概括
手术坚持显著影响局部晚期下食道癌症患者的生存率. 诸如年龄较大和远程SEER分类等因素与较低的坚持有关,预后恶化.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 癌症流行病学 癌症流行病学
背景情况:
- 食道癌是一种主要的上部胃肠道恶性瘤.
- 局部晚期下食道癌症 (IIA-IVA) 提出了重要的治疗挑战.
- 了解影响治疗坚持的因素对于改善患者的治疗结果至关重要.
研究的目的:
- 为了评估手术坚持对局部发达的食道下部癌症的生存的影响.
- 确定与手术坚持不良相关的人口和临床因素.
主要方法:
- 来自SEER数据库的4922名患有局部晚期下食道癌症的患者 (2004-2015) 的分析.
- 多因素后勤回归用于识别影响外科坚持的因素.
- 卡普兰-梅尔曲线和考克斯回归来评估坚持对整体生存期 (OS) 和癌症特异性生存期 (CSS) 的影响.
主要成果:
- 2025年,在2372名接受手术建议的患者中,有347人拒绝接受手术.
- 较低的坚持与年龄较大,未婚状态,遥远的SEER分类和状细胞癌有关.
- 拒绝手术独立降低了OS (OR: 1.657) 和CSS (OR: 1.487).
结论:
- 良好的手术坚持是局部先进的下食道癌的积极预后因素.
- 缺乏粘附性与特定的患者和疾病特征相关.
- 改善手术坚持的干预措施可能会提高这一患者群的存活率.
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