与非怀孕对照组相比,与怀孕相关的乳腺癌患者的存活率
María Martín Cameán1, Ibon Jaunarena2, Jose Ignacio Sánchez-Méndez3
1Department of Gynecology and Obstetrics, La Paz University Hospital, Madrid, 28046, Spain. Mariamartincamean@gmail.com.
Reproductive biology and endocrinology : RB&E
|March 27, 2024
概括
怀孕相关乳腺癌 (PABC) 的结局与非怀孕妇女相似,经过调整以阶段和等级. 然而,PABC通常呈现为更具侵略性的癌症.
科学领域:
- 在瘤学瘤学.
- 生殖医学 生殖医学
- 临床流行病学临床流行病学
背景情况:
- 怀孕相关乳腺癌 (PABC) 是一种罕见的疾病,预后结果有争议.
- 之前对PABC预后的研究已经产生了有争议的结果.
研究的目的:
- 为了比较被诊断患有PABC的患者的生存结果与患有乳腺癌的非怀孕患者队列.
- 研究怀孕对乳腺癌预后的影响.
主要方法:
- 一项回顾性队列研究,将34名PABC患者与55名在2009-2021年期间诊断出非怀孕的乳腺癌患者进行比较.
- 考克斯比例危险回归分析用于评估无病生存率 (DFS) 和整体生存率 (OS).
- 分析根据瘤等级和病理阶段进行了调整.
主要成果:
- 患有PABC的患者更有可能出现高度 (3级) 瘤和晚期病理阶段 (III-IV).
- 尽管瘤特征更具侵略性,但在调整了等级和阶段后,PABC和非怀孕组的整体存活率是可比的.
- 孕妇的中位随访期为47个月,对照组为46个月.
结论:
- 当考虑到瘤特征时,被诊断患有与怀孕相关的乳腺癌的妇女的预后与年轻的非怀孕个体的预后相似.
- 怀孕相关的乳腺癌的特点是更具侵略性的表型,需要在临床管理中仔细考虑.
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