遗传风险与坚持健康生活方式之间的关联,有助于发展与年龄相关的听力损失
Sang-Hyuk Jung1, Young Chan Lee1,2, Manu Shivakumar1
1Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
BMC medicine
|March 27, 2024
概括
遗传和生活方式的选择显著影响与年龄相关的听力损失 (ARHL) 风险. 采用健康的生活方式可以减轻听力损失,即使对于那些具有高遗传倾向的人来说也是如此.
科学领域:
- 遗传学和表观遗传学
- 公共卫生 公共卫生
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 生活方式和环境因素是已知的与年龄相关的听力损失 (ARHL) 的贡献者.
- 有限的研究存在于遗传学,生活方式和健康习惯对ARHL风险的联合影响.
- 这项研究调查了遗传倾向,生活方式和ARHL发育之间的相互作用.
研究的目的:
- 评估ARHL遗传变异与生活方式/环境因素之间的关联.
- 评估健康生活方式在缓解ARHL风险方面的作用.
- 检查遗传和生活方式因素对ARHL的联合影响.
主要方法:
- 一项使用英国生物库 (UKBB) 数据对376,464名欧洲人 (40-69岁) 的病例控制研究.
- 复制分析是基于宾夕法尼亚大学医学生物库 (PMBB) 的数据进行的.
- 来自GWAS的ARHL的多基因风险评分 (PRS);基于行为和环境因素计算的健康生活方式评分.
主要成果:
- 非常高的ARHL PRS与49%的ARHL风险增加有关.
- 糟糕的生活方式显著增加了ARHL风险 (调整后OR,3.03).
- 坚持健康的生活方式减轻了ARHL风险,特别是在具有高遗传风险的个体中 (调整后OR,0.21).
结论:
- 在ARHL中,遗传和生活方式因素之间存在显著的联合关联.
- 坚持健康的生活方式可以大大降低ARHL的风险,即使在遗传敏感的个体.
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