光聚合物接种聚氨的核心外结构作为生物医学应用的受控药物输送车辆
Amita Santra1, Ravi Prakash1, Swapan Maity1
1School of Materials Science and Technology, Indian Institute of Technology (BHU), Varanasi 221005, India.
ACS applied materials & interfaces
|March 27, 2024
概括
新型核心外移植共聚合物被合成用于可控的药物输送,证明了持续的药物释放和潜在的生物医学应用的增强生物相容性.
科学领域:
- 材料科学 材料科学 材料科学
- 聚合物化学 聚合物化学
- 生物医学工程 生物医学工程
背景情况:
- 开发先进的药物输送系统对于提高治疗疗效和患者治疗结果至关重要.
- 需要控制释放机制来最大限度地减少副作用并优化药物度.
- 核心外结构为封装和释放治疗剂提供了独特的特性.
研究的目的:
- 为了合成和表征用于控制药物输送的新型核心外移植共聚合物.
- 研究合成材料的药物释放动力学和生物相容性.
- 探索这些移植共聚合物的生物医学应用中的潜力,包括3D支架.
主要方法:
- 合成功能化的紫外线可光治疗双A-甘油酸二甲基酸盐作为核心,并用聚氨 (PU) 作为外.
- 使用光谱技术 (1H NMR,FTIR,UV-vis) 和形态分析 (TEM,AFM) 的表征.
- 评估热稳定性 (TGA),质性质,药物释放特征,生物相容性 (MTT测定,细胞成像,细胞粘附) 和体外疗效.
主要成果:
- 成功合成了具有调节尺寸和增强热稳定性和机械强度的核心外移植共聚合物.
- 与纯 PU 和光聚合物相比,从移植共聚合物中持续释放药物,这归因于核心-结构和药物-共聚合物相互作用.
- 与纯药物或PU中的药物相比,控制释放系统的良好生物相容性和更高的细胞杀伤效率得到证实.
- 在由移植共聚合物制成的3D支架内展示了成功的细胞生长.
结论:
- 合成的核心外移植共聚合物是控制药物输送车辆的有效材料.
- 独特的结构促进了持续的药物释放,并提高了治疗疗效.
- 这些生物相容材料对各种生物医学应用具有重大前景,包括组织工程支架.
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