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感染微环境对表面的响应性涂层用于按需释放治疗气体和抗生素

Kun Wang¹, Fan Rong¹, Haowei Peng¹

¹Frontiers Science Center for Flexible Electronics, Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering (IBME), Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, 710072, China.

Advanced healthcare materials

|March 27, 2024

概括

这项研究开发了一种用于植入物的智能涂层,该涂层可以根据需求释放硫化 (H2S) 和抗生素. 这种双重作用的涂层增强了骨的生长,有效地消除了细菌感染,提高了植入成功率.

科学领域:

生物材料科学生物材料科学
整形外科手术整形外科手术
传染性疾病传染性疾病

背景情况:

无菌松和细菌感染是 (Ti) 骨科植入物的主要并发症.
这些问题源于骨质整合不良和细菌污染.
目前的治疗方法缺乏有效的策略,可以同时控制感染和骨再生.

研究的目的:

为Ti植入物开发一种响应性涂层,以增强骨整合并消除细菌感染.
为了实现治疗硫化 (H2S) 气体和抗生素的按需释放.
创建一种涂层,促进骨愈合,同时防止植入物相关的感染.

主要方法:

在Ti表面化TiO2纳米管 (TNT),以增强生物活性,并作为抗生素储存库.
用一种对感染微环境有反应性的宏分子H2S供体层覆盖TNT.
在体外抗菌测定对格拉姆阴性 (大肠杆菌) 和格拉姆阳性 (金黄色杆菌) 细菌.
在大鼠大腿骨缺陷模型中的体内评估,以评估抗菌效率,炎症和骨质整合.

主要成果:

涂层显示持续释放低剂量的H2S,促进骨质细胞分化和迁移.
细菌入侵触发了H2S供体层的分解,导致了快速的抗生素释放和有效的感染预防.
在体外试验表明,对大肠杆菌和黄金杆菌都有显著的抗菌活性.
在体内研究中,在老鼠模型中,实现了98.7%的抗菌效率,抑制了炎症,并促进了骨质整合.

结论:

开发的响应性涂层有效地解决了Ti骨科植入物应用中的挑战.
它同时促进骨质融合,并通过控制释放H2S和抗生素消除细菌感染.
这种创新的涂层具有显著的潜力,可以改善骨科植入物的临床结果.

关键词:

的TiO2纳米管.它是一种抗菌药物,具有抗菌作用.植入物松动植入物松动与植入物相关的感染.骨质整合骨质整合

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