在口腔状细胞癌中长非编码RNAH19的表观遗传调制-A叙述性综述
Peramaiyan Rajendran1,2, Ramya Sekar3,2, Basem M Abdallah1
1Department of Biological Sciences, College of Science, King Faisal University, Al-Ahsa, 31982, Saudi Arabia.
Non-coding RNA research
|March 27, 2024
概括
口腔状细胞癌 (OSCC) 发病率正在转变,许多病例与烟草无关. 本综述探讨了H19长非编码RNA在口腔癌发生中的表观遗传作用,特别是在非住院患者中.
科学领域:
- 在瘤学瘤学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 分子生物学分子生物学
背景情况:
- 口腔状细胞癌 (OSCC) 的发病率正在增加,年龄和性别模式的显著转变,即使在非习惯性用户中也是如此.
- 大约51%的头癌与烟草使用等传统风险因素无关.
- 人们越来越认识到表观遗传因素对OSCC的发展和进展至关重要.
研究的目的:
- 审查H19长非编码RNA (lncRNA) 在口腔癌发生中的表观遗传作用.
- 研究H19作为OSCC生物标志物的潜力,特别是在没有吸烟史的患者中.
主要方法:
- 文献综述侧重于OSCC中的表观遗传机制和非编码RNA.
- 对研究H19 lncRNA在口腔癌诱导和进展中的功能进行分析.
主要成果:
- 包括H19在内的非编码RNA是显著的表观遗传调节器.
- 在各种癌症中,H19已被证明具有作为有效生物标志物的潜力.
- 在口腔致癌过程中H19的特殊作用需要更深入的研究.
结论:
- H19 lncRNA在口腔癌发生过程中起着关键的表观遗传作用.
- 了解H19的功能对于开发OSCC的新诊断和治疗策略至关重要,特别是在非住院患者中.
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