相关实验视频
Updated: Jun 29, 2025

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
Published on: January 22, 2020
响应pH的接口转换高效的口服药物递送平台,用于缓解炎症性肠病
Yingying Zhao1, Changqing Xu1, Qing Liu2
1Department of Gastroenterology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong, China.
新的口服纳米颗粒有效地将梅萨拉 (MSZ) 输送到结肠,显著改善了炎症性肠病 (IBD) 的治疗. 这种向药物输送系统通过在炎症的肠道环境中释放MSZ来增强治疗效果.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 胃肠病学 胃肠病学
背景情况:
- 炎症性肠病 (IBD) 的有效治疗需要耐胃酸的口服药物递送系统,并且能够有针对性的肠道释放.
- 目前的疗法在药物稳定性和向向炎症肠道组织的治疗方面面临挑战.
研究的目的:
- 开发新的口服复合纳米颗粒 (MSZ@PRHS) 用于向的梅萨拉 (MSZ) 输送治疗大肠炎.
- 在DSS诱导的大肠炎模型中评估MSZ@PRHS的pH响应性药物释放概况和治疗疗效.
主要方法:
- 开发装载有梅萨拉 (MSZ) 和涂有CAP聚合物膜 (MSZ@PRHS) 的粗半孔 (RHS) 纳米粒子.
- 在不同pH值下MSZ释放的体外评估,模拟胃,小肠和结肠环境.
- 在体内评估MSZ@PRHS在硫酸盐 (DSS) 诱导的急性结肠炎小鼠模型中的疗效.
主要成果:
- 在模拟的胃和小肠pH值下,MSZ@PRHS的MSZ释放率较低,但在模拟的结肠pH值下释放率较高.
- 在DSS诱导性大肠炎模型中,口服MSZ@PRHS显著减轻IBD症状,并改善治疗结果,而不是自由的MSZ.
结论:
- 开发的MSZ@PRHS纳米颗粒显示了对pH的反应,在结肠中向药物释放.
- 这种纳米复合材料平台为管理和治疗肠道疾病提供了一个有前途的策略,需要控制药物释放和长时间的停留时间.
更多相关视频
07:05Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
Published on: December 15, 2017
07:04Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients
Published on: February 11, 2017
相关概念视频
Drug Delivery: Enteral Route
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Drug Delivery: Miscellaneous Routes
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Drug Delivery: Overview
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Drugs for Treatment of Constipation-Predominant IBS
Routes of Drug Administration: Enteral
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...