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颗粒细胞殖民地刺激因子 (G-CSF) 诱导的动脉炎:一个病例报告
Masahiro Ito1, Masakazu Amari1, Akiko Sato1
1Breast Surgery, Tohoku Kosai Hospital, Sendai, JPN.
Cureus
|March 27, 2024
概括
化颗粒细胞殖民地刺激因子 (G-CSF) 很少会导致主动脉炎. 停止基化G-CSF导致乳腺癌患者的症状改善,这表明它是潜在的原因.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 药理学 药理学 是一个学科.
背景情况:
- 化颗粒细胞殖民地刺激因子 (G-CSF) 用于治疗化疗诱导的中性质衰竭.
- 罕见的动脉炎病例与基化G-CSF治疗有关.
- 大动脉炎呈现出大动脉的炎症,可能导致严重并发症.
研究的目的:
- 在乳腺癌患者中报告疑似基化G-CSF诱导的脉炎病例.
- 突出这一罕见不良事件的临床表现和诊断考虑.
- 强调在接受基化G-CSF的患者中考虑药物诱导的关节炎的重要性.
主要方法:
- 介绍了一个67岁的ER+/HER2+乳腺癌女性患者的案例研究.
- 患者接受了epirubicin/cyclophosphamide化疗,并进行基化G-CSF预防.
- 诊断评估包括实验室测试 (WBC,CRP,ESR) 和计算机断层扫描 (CT) 成像.
主要成果:
- 患者在化疗后出现发烧和关节痛.
- 实验室标记显示系统性炎症.
- 脑电图扫描显示了大动脉门和下垂大动脉的加厚,与大动脉炎一致.
- 在停止基化G-CSF后,症状显著改善.
结论:
- 在接受化疗的患者中,在对主动脉炎的差异诊断中应考虑pegylated G-CSF.
- 药物戒断后症状迅速消失是药物诱导的风炎的一个关键指标.
- 早期识别和管理,包括药物停用,对于患者的结果至关重要.
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