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在COVID-19的住院患者的特征和结果变化在四个前-Omicron波浪期间

M Martinot¹, M Eyriey², S Gravier¹

¹Infectious Diseases Department, Hôpitaux Civils de Colmar, Colmar, France.

|March 27, 2024

概括

在法国,COVID-19住院患者的特征在四个波浪中演变,早期的波浪显示出更严重的疾病和更高的死亡率. 后来的波浪看到了更年轻的患者更少的并发病,尽管有新的变异,死亡率下降.

科学领域:

流行病学流行病学
传染性疾病传染性疾病
公共卫生公共卫生

背景情况:

在2020年3月至2021年9月期间,法国发生了2019年新冠病毒病 (COVID-19) 的四个不同的波浪.
由于疫苗接种和SARS-CoV-2变种的出现等因素,COVID-19的住院患者特征发生了显著变化.

研究的目的:

在四个不同的流行浪潮中分析COVID-19住院患者特征和结果的变化.
为了比较不同波的患者人口统计,疾病严重程度和死亡率.

主要方法:

一个回顾性单中心研究包括1762名实验室验证的COVID-19住院患者.
分析了四个时期的数据:2020年3月至6月 (第1波),2020年7月至12月 (第2波),2021年1月至6月 (第3波) 和2021年7月至11月 (第4波).
结果和基线特征在四个波段进行了比较.

主要成果:

第一波的患者出现了更严重的疾病,晚些时候入院,以及更高的ICU率.
波1-3主要包括多种并发症的老年患者 (>70岁),而波4患者更年轻 (68.0岁),并发症较少.
在前两个波段 (16.8%和20.0%) 的死亡率高于后两个波段 (16.6%和9.5%).

结论:

第一波COVID-19与最严重的疾病,最高的死亡率和最大的ICU利用率有关.
尽管在第四波中出现了德尔塔变种的流行,但住院和死亡率显著下降.
这些发现突出了疫苗接种和不断变化的变种对COVID-19患者个人资料和结果的影响.

关键词:

在 COVID-19 疫情中,新冠病毒疾病2019年在SARS-CoV-2中.死亡率死亡率在前-Omicron时代.严重急性呼吸系统综合征新冠病毒2 波浪波浪波浪

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