高血压与非常老年人的认知,情绪和行为参数之间的联系:来自IlSIRENTE研究的结果
Helio José Coelho-Junior1, Riccardo Calvani1,2, Matteo Tosato2
1Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, Rome, Italy.
Frontiers in public health
|March 27, 2024
概括
非常老年人的高血压与较少的记忆问题和较低的炎症标志物有关. ангиотензин转化酶抑制剂 (ACEI) 的使用可能会影响这些关联.
科学领域:
- 老年学是一门学科.
- 心血管健康 心血管健康
- 神经科学是一个神经科学.
背景情况:
- 关于高血压对老年人认知,情绪和行为的影响,有不同的发现.
- 之前的研究可能没有充分调整用于血管激素转化酶抑制剂 (ACEI) 的使用,这是一个常见的高血压药物.
- 了解这些关联对于管理老龄人口的健康至关重要.
研究的目的:
- 检查高血压参数,ACEI使用和非常老年人的认知功能,情绪和行为症状之间的横截面关联.
- 在这个人口群体中研究高血压和炎症标志物之间的关系.
- 澄清ACEI在观察到的关联中的作用.
主要方法:
- 对IlSIRENTE前性队列研究 (n=364) 的分析,包括80岁及以上的个人.
- 在休息后评估血压 (BP),认知功能,情绪和行为症状,使用标准化仪器 (最低数据集家庭护理).
- 血液炎症标志物的测量和药物使用的编码 (解剖治疗化学代码).
主要成果:
- 与高血压相关的参数在同变量调整后与各种认知,情绪和行为参数显著相关.
- 在高血压和较少的短期记忆问题之间发现了反向关联.
- 与正常血压患者相比,高血压患者的炎症标志物血度较低.
结论:
- 血压升高与非常老年人的记忆力投诉较少有关.
- 在高血压患者中观察到较低的炎症标志物度.
- 使用ACEI可能会调节高血压和认知/行为结果之间的关系.
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