来自武汉的塔拉罗米科斯:两例病例报告和文献综述
Zhiyuan Yao1, Zhou Pan1, Guang Li1
1Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Frontiers in cellular and infection microbiology
|March 27, 2024
概括
塔拉罗米科斯是一种危险的真菌感染,在免疫受损的个体. 早期诊断和治疗对于生存至关重要,因为延迟护理往往会导致致命的结果.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 免疫功能受损的宿主
背景情况:
- 由*Talaromyces marneffei*引起的塔拉罗米科斯是一种机会性感染,主要影响免疫力低下的人.
- 在东南亚和南亚普遍存在,它也发生在非特有地区,构成全球健康挑战.
- 这种疾病缺乏特定的临床症状,导致诊断困难和高死亡率.
研究的目的:
- 突出诊断挑战和与免疫功能受损患者的塔拉罗米科斯相关的不良预后.
- 强调需要提高临床怀疑和及时干预talaromycosis的必要性.
主要方法:
- 介绍了两项病例研究,涉及患有塔拉罗米科斯的免疫受损患者.
- 对临床表现,实验室发现,诊断程序和治疗结果的审查.
- 微生物培养和成像结果的分析.
主要成果:
- 两位患者都出现了发烧,贫血,疲劳和皮肤病变,以及其他特定症状,如胃肠道出血或呼吸困扰.
- 实验室测试显示血小板减少,低albuminemia,炎症标志物 (中性粒细胞比率,甲,CRP) 的升高,肝功能异常,和凝血功能障碍.
- 在这两种病例中,Talaromyces marneffei通过培养得到证实,其中一名患者也同时感染了Candida parapsilosis和Pneumocystis jirovecii. 尽管接受了治疗,但这两名患者都因感染而死亡.
结论:
- 塔拉罗米科斯的特点是潜伏的发病,不典型的表现和诊断挑战.
- 在免疫受损患者中,迅速识别和管理对于降低死亡率至关重要.
- 由于死亡率高,需要提高对塔拉罗米科斯的认识和及时干预.
相关概念视频
01:05Single Nucleotide Polymorphisms-SNPs
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
01:31Pulmonary Tuberculosis III
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
01:23Mitral Stenosis II: Clinical features and Diagnostic Tests
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
01:23Investigation of Disease Outbreaks
Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...