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骨髓系衍生抑制细胞的积累诱导Treg扩张并调节肺恶性瘤进展

Yinghua Wan¹, Xiangdong Mu¹, Jingquan Zhao¹

¹Department of Respiratory and Critical Care Medicine, Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, P.R. China.

Biomedical reports

|March 27, 2024

概括

骨髓原抑制细胞 (MDSCs) 在肺癌中累积,具有影响T细胞反应的特定子集. 这些表达PD-L1/PD-L2的细胞促进调节性T细胞扩张,可能阻碍抗瘤免疫力.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
细胞生物学细胞生物学

背景情况:

骨髓原抑制细胞 (MDSCs) 是癌症免疫抑制的关键调节者.
MDSCs是一组异质的髓状细胞,可以抑制T细胞的反应.
了解MDSC子集及其在肺癌中的作用对于开发免疫疗法至关重要.

研究的目的:

为了研究T细胞和MDSC子集在肺癌中的作用.
分析肺癌患者T细胞和MDSC的表型特征.
探索MDSC子集和调控性T细胞 (Tregs) 在肺恶性瘤中的关系.

主要方法:

分析了102例肺癌病例和34例健康对照.
流细胞测量用于对外围血液中T细胞和MDSC亚组的鉴定和表型表征.
试验室共培养试验评估MDSCs对T细胞亡和Treg分化的影响.

主要成果:

与健康对照组相比,肺癌患者表现出表达PD-L2和PD-L1的粒细胞样MDSC (G-MDSC) 的频率较低.
在肺癌患者中观察到表达PD-L1的单细胞样MDSC (M-MDSC) 的更高频率.
G-MDSCs和M-MDSCs的频率与PD-1+和CTLA-4+调节性T细胞 (Tregs) 有正相关.
在体外,来自肺癌患者的M-MDSC增强了天真T细胞亡并促进了Treg分化.

结论:

MDSC子集在肺恶性瘤中积累,并有助于免疫抑制.
表达PD-L1和PD-L2的MDSC诱导Treg扩张,可能通过PD-1相互作用.
这些发现突出了MDSC作为肺癌免疫治疗中的潜在治疗点.

关键词:

在PD-1中使用PD-1.在PD-L1中.在PD-L2中使用.调节T细胞的T细胞调节细胞.肺癌是一种肺癌.骨髓系衍生抑制细胞抑制细胞

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