协调IV氧化与儿科外科手术期药物:通过Y型连接器进行兼容性研究
Souha H Youssef1, Alka Garg2, Yunmei Song1
1Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Drug design, development and therapy
|March 27, 2024
概括
静脉注射的氧化在物理上与常用的药物和IV液体相兼容. 这项研究证实了其同时使用的安全性,防止了手术患者的疼痛恶化.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
- 药物兼容性研究 药物兼容性研究
背景情况:
- 通过Y连接器同时使用多种静脉注射 (IV) 药物是住院和手术患者的标准做法.
- 对身体不相容性的担忧限制了IV氧化与其他药物的同时使用,可能会加剧急性疼痛.
- 有限的数据存在于IV氧化与经常同时服用的药物和IV液体的物理兼容性.
研究的目的:
- 评估IV氧与常见药物和IV液体的物理兼容性.
- 提供数据,可以在术后护理中提供安全的联合管理实践的信息.
- 为了解决可能导致因药物不兼容性担忧而导致低于最佳疼痛管理的担忧.
主要方法:
- 在1:1的比率下制备了IV氧化 (1mg/ml) 与各种药物和IV液体的混合物.
- 评估包括视觉检查 (降水,度,颜色变化,气体形成),光谱测量和0分钟和60分钟的pH变化.
- 测试的药物包括胺,特拉马多尔,克隆,万科米辛,皮佩拉西林/塔扎巴克坦,德克斯米德托米丁,塞福塔克西姆,热胺,,以及几种常见的静脉注射液和TPN溶液.
主要成果:
- 在任何混合物中,IV氧化 (1mg/mL) 没有显示出任何视觉变化.
- 在350,410或550nm时没有观察到光谱光度吸收变化.
- 对于任何测试组合,在0或60分钟内都没有发生显著的pH变化 (>0.5).
结论:
- 以1mg/mL的IV氧化在物理上与所有测试药物和1:1的IV液体相容,至少60分钟.
- 调查结果支持与这些药物同时使用IV氧,并遵守欧洲共识会议标准.
- 这些兼容性数据可以帮助预防输液中断,并改善外科手术期间的急性疼痛管理.
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