与免疫检查点抑制剂相关的来源不明的发烧
Xu Tong1, Tao Zhan1, Xiaoqin Dong2
1The Second Clinical Medical College, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Frontiers in immunology
|March 27, 2024
概括
免疫检查点抑制剂 (ICI) 可以在癌症患者中引起源不明的发烧 (FUO). 本综述探讨了ICI相关的FUO机制,原因以及与传统FUO的比较.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 内部医学 内部医学
背景情况:
- 自2014年以来,免疫检查点抑制剂 (ICI) 已经改变了癌症治疗.
- 随着ICI的广泛使用,越来越多地认识到包括发烧在内的不良影响.
- 在接受治疗的癌症患者中,源不明发烧 (FUO) 带来了独特的挑战.
研究的目的:
- 引入与ICI相关的FUO概念.
- 探索ICI诱导的发烧和免疫相关不良事件 (irAEs) 背后的免疫机制.
- 总结和比较ICI相关的FUO与常规FUO的病因.
主要方法:
- 文献综述侧重于ICI治疗和相关发烧.
- 分析涉及免疫激活和细胞因子升高的拟议机制.
- 对ICI相关的FUO和传统的FUO进行比较的审查.
主要成果:
- 与ICI相关的FUO是一个独立的临床实体.
- 常见的机制包括免疫系统的激活和细胞因子的升高.
- 与ICI相关的FUO的病因与传统的FUO不同.
结论:
- 了解ICI相关的FUO对于管理癌症患者使用这些疗法至关重要.
- 将ICI相关的FUO与其他发烧原因区分开来,对于适当的患者护理至关重要.
- 需要进一步的研究来完善ICI引起的发烧的诊断和管理策略.
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