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Updated: Jun 29, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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发现一种强效,选择性和细胞活性的SPIN1抑制剂

Yan Xiong1, Holger Greschik2, Catrine Johansson3

  • 1Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.

Journal of medicinal chemistry
|March 27, 2024
PubMed
概括

研究人员开发了包括选择性SPIN1抑制剂MS8535在内的新型化学工具,以准甲基氨酸读取蛋白SPIN1,这对人类疾病至关重要. 这些化合物有助于研究SPIN1.

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