暴露于离子银对与伤口相关的细菌病原体的可变效应
Reem Binsuwaidan1,2, Osama Almuzaini1,3, Steven Mercer1
1Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Stopford Building, M13 9PT, United Kingdom.
Letters in applied microbiology
|March 27, 2024
概括
反复暴露于酸银并没有在伤口细菌中产生银的耐药性. 然而,一种Pseudomonas aeruginosa菌株显示生物膜形成和毒性增加,这是可逆的.
科学领域:
- 微生物学 微生物学
- 伤口愈合 治愈 伤口愈合
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 银化合物被用于伤口包裹,以减少细菌负载.
- 在慢性伤口中,长时间暴露于亚治疗性抗微生物度可能会发生.
- 了解细菌对银的适应对于有效的伤口护理至关重要.
研究的目的:
- 研究离子银暴露对慢性伤口细菌的表型影响.
- 评估细菌易感性,生物膜形成和毒性的变化.
- 为了确定白银在特定暴露条件下是否会产生电阻.
主要方法:
- 对 Pseudomonas aeruginosa,金黄色葡萄球菌和大肠杆菌暴露于银酸盐.
- 对浮游生物的敏感性进行微稀释敏感性测试.
- 水晶紫色生物膜测定和病原发生模型用于表型特征.
主要成果:
- 在任何测试的细菌中都没有显著的浮游生物银抗性.
- 黄金葡萄球菌 (Staphylococcus aureus) 的最低杀菌度呈现可逆性增加.
- 来自的Pseudomonas aeruginosa菌株表现出增加的生物膜形成,减少的生物膜消除度和增强的毒性,所有这些都是银取消后可逆的.
结论:
- 慢性伤口细菌对离子银的表型适应通过除浮游生物抵抗之外的其他机制发生.
- 在Pseudomonas aeruginosa中增加生物膜形成和毒性对伤口管理策略有潜在的影响.
- 进一步的研究是有必要的,以了解和解决银诱导的伤口细菌的表型变化.
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