在接受药物辅助治疗的患者中对布普伦诺芬的监测
Amadeo Pesce1, Katie Bollman2, Kevin Krock2
1Precision Diagnostics LLC, San Diego, California. ORCID: https://orcid.org/0000-0003-3748-9703.
Journal of opioid management
|March 27, 2024
概括
尿液和口腔液体的药物检测有效监测阿片类药物依赖的药物辅助治疗患者的布普伦诺芬坚持,建立预期的药物度模式.
科学领域:
- 药理学 药理学 是一个学科.
- 毒理学 毒理学 毒理学
- 临床化学 临床化学
背景情况:
- 布普伦诺芬是治疗阿片类药物依赖的关键药物.
- 监测患者的坚持是有效治疗结果的关键.
研究的目的:
- 确定布普伦诺芬及其代谢物诺布普伦诺芬的预期药物度模式.
- 验证尿液和口腔液体测试,以监测药物服药.
主要方法:
- 使用液体染色学-并联质谱法进行定量分析.
- 定义了布普伦诺芬和诺布普伦诺芬的分泌模式.
主要成果:
- 开发了布普伦诺芬和诺布普伦诺芬度的频率分布曲线.
- 这些曲线代表了布普伦诺芬治疗患者预期的药物水平.
结论:
- 尿液和口腔液体药物检测是可靠的方法,用于遵守监测.
- 这种监测支持有效的药物辅助治疗阿片类药物依赖.
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