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血液标记物显示长期COVID-19的神经后果
Norina Tang1, Tatsuo Kido1, Jian Shi2,3
1Department of Laboratory Medicine, San Francisco VA Health Care System, San Francisco, CA 94121, USA.
Cells
|March 27, 2024
概括
长期COVID幸存者显示炎症和压力标志物增加. 细胞外囊中的神经退行性蛋白质表明,即使在COVID-19感染后没有持续症状,神经元功能障碍也存在.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- 全球超过6500万个人经历了COVID-19后的后果 (长期COVID).
- 神经症状在长期COVID幸存者中很常见,因此需要识别神经标志物.
- 了解SARS-CoV-2感染对神经系统的影响至关重要.
研究的目的:
- 通过分析血和神经元丰富的细胞外囊 (nEVs) 来识别与长期COVID相关的神经标记物.
- 研究长期COVID患者,没有症状的COVID-19幸存者和健康对照者之间的可溶生物分子和nEV蛋白质的差异.
主要方法:
- 从33名长期COVID患者中收集了血和nEVs神经功能障碍 (nLongC),12名COVID-19幸存者 (Cov) 和28名健康对照者 (HC).
- 分析了溶性生物分子 (例如IL-1β,IL-8,BDNF,皮质醇) 和nEV中的蛋白质 (例如粉样β42,pTau181,TDP-43).
- 参与者在2020-2022年间感染,没有住院治疗,疫苗接种情况各不相同.
主要成果:
- 在nLongC和Cov组中增加IL-1β;在nLongC组中增加IL-8.
- 与HC相比,在nLongC和Cov组中增加了来自大脑的神经营养因子 (BDNF) 和皮质醇.
- 来自nLongC患者的nEV显示神经元功能障碍的标志物显著升高 (粉样β42,pTau181,TDP-43).
结论:
- COVID-19 感染与慢性外周炎症和增加的压力有关.
- 在从COVID-19中恢复过来的个体中,在nEV中分别表达的神经退行性蛋白被确定,无论持续的症状如何.
- 这些发现表明,在SARS-CoV-2感染后,可能会产生长期的神经影响.
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