在生殖阶段暴露于Rebaudioside A的心脏代谢影响
Isabella Bracchi1,2,3, Juliana Morais2,3,4, João Almeida Coelho4,5
1Unit of Biochemistry, Department Biomedicine, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.
Biology
|March 27, 2024
概括
长期食用甜醇甜味剂Rebaudioside A (RebA) 在雌性大鼠繁殖期间没有显示任何不良心脏代谢影响. 需要进一步的研究来评估后代的安全性.
科学领域:
- 毒理学 毒理学 毒理学
- 心血管科学 心血管科学
- 代谢科学 代谢科学
背景情况:
- 非糖甜味剂 (NSS) 的消费量正在增加,特别是在怀孕期间.
- 监管机构对NSS安全性提出了不同的建议,需要进一步研究.
- 红豆酸A (RebA) 是一种源自牛的甜味剂,被广泛使用,但其长期生殖安全性需要研究.
研究的目的:
- 为了研究长期在生殖阶段摄入Rebaudioside A (RebA) 的线粒体和心脏代谢影响.
- 评估RebA对心脏结构,功能和线粒体健康的影响.
- 为了评估RebA对葡萄糖和脂质平衡的影响.
主要方法:
- 雌性大鼠从交配前到断奶时接受了RebA (4mg/kg/天).
- 评估了形态测量,食物/水摄入量,葡萄糖/脂质概况以及心脏/线粒体功能.
- 评估心脏结构,心肌细胞大小,纤维化和肌纤维功能.
主要成果:
- RebA诱导了对心脏的轻微缩作用,减少心肌细胞大小和心肌纤维化.
- 没有观察到对心脏功能,线粒体功能或肌纤维功能的不良影响.
- 禁食葡萄糖和总胆固醇水平下降,而葡萄糖耐受性和胰岛素敏感性没有受到影响.
结论:
- 研究的RebA剂量似乎对女性在生殖过程中的心脏代谢健康是安全的.
- 需要进一步的研究来确定RebA暴露对后代发育的影响.
- 这些发现有助于了解在生殖生命周期期间基于豆的甜味剂的安全性.
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