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机械循环支对上升大动脉血流的影响:一项综合实验和计算研究

Sapir Hazan Shenberger¹, Idit Avrahami¹

¹Department of Mechanical Engineering and Mechatronics, Ariel University, Ariel 40700, Israel.

Bioengineering (Basel, Switzerland)

|March 27, 2024

概括

机械循环支持 (MCS) 装置影响大动脉流动. 的设计显著改变了流动模式,反时钟方向 (CCW) 驱动器旋转创造了非生理流动,而时钟方向 (CW) 旋转更符合自然的大动脉血动力学.

科学领域:

生物医学工程生物医学工程
心血管流动的动力学
医疗器械血液动力学医疗器械血液动力学

背景情况:

穿皮机械循环支持 (MCS) 装置对于急性失偿性心力衰竭至关重要,作为移植或恢复的桥梁.
与MCS治疗相关的并发症可能来自于它们在主动脉内的血液动力学影响.
了解这些血液动力学影响对于优化MCS设备设计和患者结果至关重要.

研究的目的:

为了研究不同皮肤通道机械循环支持 (MCS) 装置配置对大动脉血流动力学的影响.
分析旋方向和喷气型对大动脉内流体结构,流和螺旋形状的影响.
为了比较各种MCS诱导的流动模式与自然大动脉血动力学的生理相容性.

主要方法:

结合实验和数值方法被用于研究大动脉流动.
粒子图像速度测量 (PIV) 用于捕捉大动脉物理玻璃模型中的旋转和流特征.
进行了计算流体动力学 (CFD) 分析,以实现对血液流动模式的全面3D理解.

主要成果:

MCS的配置显著影响胸前大动脉流动力学.
带有旋转螺旋的吸气诱导主导的旋转流,可以分配喷气并减少大动脉门附近的流.
反时钟方向 (CCW) 螺旋旋转会在下降的大动脉中产生一种非生理性的CCW螺旋流,与自然流形成对比;时钟方向 (CW) 旋转显示出与自然螺旋流模式的更好整合.

结论:

MCS 设备的设计,特别是螺旋旋转,极大地影响了大动脉血动力学.
由MCS装置诱导的顺时针 (CW) 旋转流似乎比逆时针 (CCW) 旋转更符合下降大动脉的自然流动模式.
这些发现强调了在MCS设备的设计中考虑旋流效应的重要性,以尽量减少潜在的并发症并改善患者的治疗结果.

关键词:

在 CFD 交易中,我们可以看到 CFD.在 PIVIV 中.这就是TKE TKE TKE.大动脉的流动通过皮肤提供MSC.

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