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喷雾干燥的奇托桑水凝颗粒作为西达胺化的潜在输送系统

Sofia Milenkova¹, Rita Ambrus², Mahwash Mukhtar²

¹Faculty of Physics and Technology, University of Plovdiv "Paisii Hilendarski", 24 Tsar Asen Str., 4000 Plovdiv, Bulgaria.

Gels (Basel, Switzerland)

|March 27, 2024

概括

低分子量奇托桑微粒被开发为胺化的药物输送系统. 这些生物相容的水凝显示出口服药物输送的潜力,韦布尔模型准确地描述了药物释放动力学.

科学领域:

材料科学材料科学材料科学
聚合物化学聚合物化学
制药科学制药科学

背景情况:

奇托是一种首选的生物相容性和粘粘性多糖体,用于药物输送中的水凝形成.
低分子量奇托为开发新型药物输送系统提供了潜力.

研究的目的:

从低分子量奇托桑制造喷雾干燥的微粒,用于胺化的输送.
为了研究交叉链接 (三聚酸) 和涂层 (曼尼托尔) 对酸盐颗粒性质的影响.
评估这些微粒作为口腔货物系统的潜力.

主要方法:

喷雾干燥技术,以产生基托微粒 (1-10微米).
使用扫描电子显微镜 (SEM),富里埃变换红外光谱学 (FTIR),差分扫描热度计 (DSC) 和X射线粉状衍射 (XRPD) 的表征.
在模拟的唾液缓冲器 (pH 6.8) 和数学建模 (韦布尔模型) 中研究药物释放动力学.

主要成果:

通过SEM观察到空和药物载荷的基托微粒的球形和正规形态.
FTIR,DSC和XRPD证实了药物聚合物相互作用和胺化物在矩阵内的相变.
使用韦布尔分布,药物释放动力学成功建模.

结论:

喷雾干燥的低分子量奇多微粒是胺化的合适载体.
交叉连接和曼尼托尔涂层影响了基托水凝结构的特性.
这些微粒显示出口服药物递送应用的潜力,释放动力学可预测.

关键词:

基胺化物化物基多酸盐的使用方法控制药物输送的控制药物输送.基于凝的微粒.喷雾干燥喷雾干燥

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