开发适应pH,热敏,抗菌和抗癌的CS/PVA/石墨烯混合凝,用于控制药物输送
Saira Mansha1, Amna Sajjad1, Aneeqa Zarbab1
1Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Punjab, Pakistan.
Gels (Basel, Switzerland)
|March 27, 2024
概括
这项研究开发了一种以石墨烯为基础的水凝,加载了用于肝癌治疗的甲醇. 这种新型药物输送系统显示出可控释放和降低毒性,为肝细胞癌提供了有前途的治疗方法.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 癌症治疗方法 癌症治疗方法
背景情况:
- 聚合物药物输送系统旨在提高溶解性,减少副作用,并使有针对性的药物管理.
- 石墨烯板 (GNS),聚乙醇 (PVA) 和酸盐 (CS) 在先进的水凝配方中被探索其潜力.
- 甲甲酸 (MTX) 是一种用于癌症治疗的化疗剂.
研究的目的:
- 开发和表征一种新型的配聚合物凝 (GNS-PVA-CS) 加载有甲状腺酸盐 (MTX).
- 评估MTX装载水凝用于肝癌治疗的体外疗效,特别是针对肝细胞癌.
- 评估开发的水凝系统的安全性和药物释放概况.
主要方法:
- 使用石墨烯板 (GNS),聚乙醇 (PVA) 和奇托 (CS) 制造共聚合物水凝.
- 在GNS-PVA-CS水凝矩阵中加载甲基酸盐 (MTX).
- 使用富里埃变换红外光谱 (FTIR) 和原子力显微镜 (AFM) 进行了表征.
- 在PBS (pH 7.4) 中的体外评估包括胀,降解,细胞毒性 (HepG2细胞),溶血活性和药物释放动力学 (pH 7.4).
主要成果:
- 在GNS-PVA-CS水凝中,MTX的释放受到控制,在6小时内最大释放率为97.34%.
- 水凝显示出非溶血性质,并没有促进HepG2细胞的增殖.
- 装有MTX的水凝显示出与免费MTX对HepG2细胞的细胞毒性相当 (IC50 5.87 μg/200 mL与5.03 μg/200 mL),表明局部有效性.
- 通过FTIR和AFM证实了结构和形态特性.
结论:
- 开发的基于GNS的含有MTX的水凝代表了治疗肝细胞癌的有前途的药物输送系统.
- 水凝促进了瘤微环境中的药物递送,同时最大限度地减少了对健康细胞的不良影响.
- 这种GNS-PVA-CS-MTX水凝具有作为肝癌有效和更安全的治疗策略的潜力.
相关概念视频
Modified-Release Drug Delivery Systems: Rate-Programmed II
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Classification
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Rate-Programmed I
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Modified-Release Drug Delivery Systems: Stimuli-Activated
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Site-Targeted
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...


