英古拉多斯细菌与抗生素对抗多药耐药病原体的协同活性
Javier Blanco-Blanco1,2, María Bravo1, Irene Simón1
1Ingulados, S.L., 10004 Cáceres, Spain.
Antibiotics (Basel, Switzerland)
|March 27, 2024
概括
乳酸细菌发酵产品,特别是来自BAL16的乳酸细菌,在对抗多药耐药性感染方面表现有前途. 这些化合物被称为细菌素,增强了抗生素对抗耐药细菌的有效性,如Enterococcus faecium.
科学领域:
- 微生物学 微生物学
- 生物技术是生物技术.
- 传染性疾病 传染性疾病
背景情况:
- 抗菌素耐药性 (AMR) 构成了全球健康的重大威胁,需要新的治疗策略.
- 过度依赖常规抗生素加快了多药耐药 (MDR) 病原体的出现.
- 替代性抗微生物解决方案对于治疗医院感染至关重要.
研究的目的:
- 评估乳酸细菌 (LAB) 发酵产品对临床MDR病原体的抗菌潜力.
- 研究LAB化合物与常规抗生素的协同作用.
- 描述负责抗微生物活性的活性成分.
主要方法:
- 从临床样本中分离和选择MDR菌株 (大肠杆菌,肺炎菌,菌菌,菌).
- 对来自Ingulados LAB收集的发酵产品进行测试.
- 使用克板测试和分数抑制度指数 (FICI) 的协同效应评估.
- 生物信息分析和超处理方法用于化合物表征.
主要成果:
- BAL16发酵产品对MDR Enterococcus faecium表现出显著的抑制活性.
- 在BAL16化合物和四环素之间观察到协同效应.
- 生物信息学和表面分析确定了细菌素是关键的抗菌剂.
结论:
- 来自LAB菌株BAL16的发酵产品,特别是细菌素,是对抗MDR Enterococcus faecium感染的有希望的替代品.
- 将BAL16产品与四环素结合使用,可以提高抗微生物药物的有效性.
- 进一步的研究是有必要的,以全面描述这些细菌素的治疗开发.
相关概念视频
Combined Effects of Drugs: Synergism
3.9K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
3.9K
Antibiotic Selection
53.4K
Overview
53.4K
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Antimicrobial Proteins
985
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
985


