在小农牛群中使用抗菌素的区域范围分析 (意大利阿奥斯塔山谷):为什么监测很重要
Federico Scali1, Sandra Ganio2, Claudio Roullet2
1Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, 25124 Brescia, Italy.
Antibiotics (Basel, Switzerland)
|March 27, 2024
概括
意大利牛群中抗菌剂的使用率很低,但呈现下降趋势. 关键药物使用和乳内治疗需要注意优化抗菌药物管理.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 抗微生物耐药性 抗微生物耐药性
- 一个健康,一个健康.
背景情况:
- 在牲畜中优化抗微生物药物使用 (AMU) 对于打击抗微生物药物耐药性 (AMR) 至关重要.
- 在阿奥斯塔山谷等地区普遍存在的小型农场,为AMU监测带来了独特的挑战.
- 了解不同农业环境中的AMU模式对于有效的AMR策略至关重要.
研究的目的:
- 分析11年间意大利牛群中抗菌剂使用 (AMU) 的趋势.
- 在一个由小型农场主导的地区,调查畜群规模和AMU之间的关系.
- 确定需要针对性的干预措施的特定抗微生物药物类别和注射途径.
主要方法:
- 分析了2008-2018年间1000多个牛群的AMU数据.
- 用意大利的定义每日剂量动物 (DDDAit) 估计每种生物量和治疗发生率 (TI100) 的AMU.
- 统计分析以检测时间趋势和与群体大小的相关性.
主要成果:
- 平均每年群体水平的AMU很低 (3.6DDDAit/生物质, 1.2TI100在牛中).
- 在总AMU中观察到显著的下降时间趋势,以及与群体大小的积极相关性.
- 关键的抗微生物药物 (如头素) 占使用量的近10%,乳内产品超过60%.
结论:
- 虽然整体AMU低,趋势下降,但高比例的关键抗微生物药物和乳内使用需要集中优化策略.
- 在小型农场环境中监测AMU对于确定改善领域和实施谨慎使用抗菌素至关重要.
- 需要进一步的干预来完善AMU实践,即使在一般使用较低的环境中,也需要有效地减轻AMR风险.
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