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相关概念视频

siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
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Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

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The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...
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Experimental RNAi02:15

Experimental RNAi

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

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Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
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Types of RNA01:23

Types of RNA

63.6K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
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RNA Interference01:23

RNA Interference

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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
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相关实验视频

Updated: Jun 29, 2025

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

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在理性药物开发中的反意义和功能核酸.

Robert Penchovsky1, Antoniya V Georgieva1, Vanya Dyakova1

  • 1Laboratory of Synthetic Biology and Bioinformatics, Faculty of Biology, Sofia University, "St. Kliment Ohridski", 8 Dragan Tzankov Blvd., 1164 Sofia, Bulgaria.

Antibiotics (Basel, Switzerland)
|March 27, 2024
PubMed
概括

反感和功能性核酸提供合理的药物设计,降低成本和提高成功率. 这些基于RNA的工具既可以作为药物标,也可以作为有效药物开发的治疗方法.

关键词:
反感的寡核化物.反感性疗法是一种反感性疗法.药物输送是药物输送的过程.发现药物的发现.核酸工程是核酸的工程.带丝切换器 带丝切换器ribozymes ribozymes ribozymes 是一种类型的有机化合物.

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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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科学领域:

  • 生物技术是生物技术.
  • 分子生物学分子生物学
  • 药物发现 药物发现 药物发现

背景情况:

  • 核酸在药物开发中扮演着双重角色,作为标和治疗药物.
  • RNA的点包括信使RNA,非编码RNA和 ribozyme.
  • 反意义和功能核酸是药物发现的宝贵工具.

研究的目的:

  • 审查药物开发中的反感和功能核酸的设计原则,应用和前景.
  • 突出基于RNA的方法在合理的药物设计和目标评估方面的潜力.
  • 为制药行业和患者带来益处,推广基于RNA的新策略.

主要方法:

  • 关于反感和功能性核酸的现有文献的审查.
  • 讨论基因表达机制的基于RNA的控制.
  • 探索用于新药发现的工程方法.

主要成果:

  • 反理性寡核酸,合成 ribozymes 和 siRNAs 是功能核酸的关键例子.
  • 这些分子使合理的药物设计成为可能,提高了效率和成功率.
  • 基于RNA的药物开发为抗菌疗法提供了新的途径.

结论:

  • 反意义和功能核酸代表了合理药物设计的强大平台.
  • 这些方法可以显著减少药物开发时间和成本.
  • 基于RNA的疗法对未来的医学有很大的前景.