在新生儿重症监护病房治疗持续凝血酶阴性葡萄球菌细菌症时使用达普托米辛
Eleni Papachatzi1, Despoina Gkentzi2, Sotiris Tzifas1
1Neonatal Intensive Care Unit, University General Hospital of Patras, 26504 Patras, Greece.
Antibiotics (Basel, Switzerland)
|March 27, 2024
概括
达普托米辛有效地治疗了早产新生儿的持续凝血酶负型葡萄球菌菌病. 这种抗生素表现出良好的安全性,大多数婴儿获得了阴性血液培养和成功的结果.
科学领域:
- 新生儿医学 新生儿医学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 晚发性败血症 (LOS) 的发生率在早产新生儿中正在上升.
- 在LOS中,持久性细菌血症 (PB) 需要积极的治疗.
- 关于新生儿持续凝固性阴性葡萄球菌 (CoNS) 细菌病的达普托米辛的数据有限.
研究的目的:
- 评估达普托米辛在新生儿持续性CoNS细菌病的疗效和安全性.
- 评估托米辛对新生儿队列临床结果和不良事件的影响.
主要方法:
- 回顾性,观察性,单中心研究.
- 分析的新生儿在2011-2022年期间接受了针对PB的达普托米辛治疗.
- 包括在第三级新生儿重症监护病房 (NICU) 中患有 CoNS 细菌病的婴儿.
主要成果:
- 十二名患有PB的新生儿接受了达普素治疗 (每天两次6毫克/千克/剂量).
- 在12名婴儿中,有11名 (91.7%) 通过负血培养成功接受治疗.
- 没有观察到脏,肝脏,肌肉或胃肠道的不良事件;一个新生儿有发作.
结论:
- 达普托米辛单独治疗在早产新生儿中显示出足够的治愈率,这些新生儿患有持续的CONS细菌血症.
- 达普托米辛在这个新生儿队列中是有效和耐受的.
- 需要进行更大规模的研究和随机对照试验来确认达普托米辛的安全性.
相关概念视频
Healthcare Associated Infections II: Preventive Measures
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Pneumonia IV: Management
The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Acute Pyelonephritis II: Diagnostic Studies and Management
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Staphylococcal Skin Infections
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Bacterial Meningitis
Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Clinical Significance of Antibiotic Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...


