自然化合物的抗菌作用机制从内生菌微生物中分离出来的自然化合物
Farkhod Eshboev1,2,3,4, Nilufar Mamadalieva1,2,3, Pavel A Nazarov5
1S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan, Mirzo Ulugbek Str. 77, Tashkent 100170, Uzbekistan.
Antibiotics (Basel, Switzerland)
|March 27, 2024
概括
内生菌微生物产生具有抗菌潜力的新型化合物,用于对抗日益增长的抗生素耐药性. 这篇评论探讨了它们的机制,对抗耐药细菌的活性,以及生物合成基因集群.
科学领域:
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
- 生物技术是生物技术.
背景情况:
- 抗生素耐药性构成了全球严重的健康威胁,需要新的抗菌药物发现.
- 生活在植物组织中的内性微生物是各种生物活性二次代谢物的丰富来源.
- 现有的研究已经从内植物中确定了许多抗微生物化合物,但对它们的机制和对耐药菌株的影响的全面研究是有限的.
研究的目的:
- 审查抗微生物药物和内菌衍生二次代谢物的作用机制.
- 分析内生菌衍生的天然化合物对抗抗生素耐药细菌的抗菌活性.
- 讨论负责生产这些有价值的二次代谢物的内菌中的生物合成基因集群.
主要方法:
- 关于内菌衍生抗微生物药物的当前研究结果的综合文献综述.
- 对细菌细胞作用机制详细研究的分析.
- 对抗抗生素耐药细菌菌株的活性研究的评估.
- 在内菌中对已识别的生物合成基因集群的研究.
主要成果:
- 内生菌微生物产生各种具有显著抗微生物潜力的二次代谢产物.
- 这些化合物的子集对抗生素耐药细菌表现出有前途的活性.
- 这些化合物的作用机制和生物合成途径正在越来越多地被阐明.
结论:
- 源自内菌的二次代谢物是开发新抗菌疗法的重要资源.
- 对它们的机制和生物合成途径的进一步研究对于药物开发至关重要.
- 用来自内细胞的新型化合物向抗生素耐药性提供了一个有前途的治疗策略.
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